Fantasy Football injury report Week 4: Lamar Jackson, Puka Nacua, Justin Jefferson & more

Week 4 of the NFL season is bringing another wave of injury questions for fantasy football managers. Several major stars are trending in the right direction, while others are creating legitimate concern heading into the weekend.

🚨 Fantasy Football News Updates You Need to Know

• Puka Nacua said he practiced fully but was limited
• Justin Jefferson sat out a second straight practice
• DeVonta Smith is not expected to play in Week 4
• Travis Etienne was placed on injured reserve
• D'Andre Swift was… pic.twitter.com/JHruiIEGi9

— RotoWire Fantasy Football (@RotoWireNFL) October 2, 2026

Here is the latest injury news on Lamar Jackson, Puka Nacua, Justin Jefferson, DeVonta Smith, D’Andre Swift, Ladd McConkey and more.

MORE:Fantasy Football studs & duds for Week 4 of 2026 NFL season

Biggest injury updates heading into Week 4

Puka Nacua was limited Thursday despite saying he practiced fully, but the Rams remain optimistic about his availability. Nico Collins also remained limited and is trending toward a return, while Lamar Jackson and Zay Flowers both practiced fully for Baltimore.

Justin Jefferson, meanwhile, sat out a second straight practice after suffering an ankle injury in Week 3. DeVonta Smith also remained out of practice and is not expected to play against the Buccaneers.

The running back position has plenty of uncertainty. Travis Etienne was placed on injured reserve, while D’Andre Swift was downgraded to a DNP Thursday with a knee injury. Breece Hall also missed practice again, while Bucky Irving remained limited. Tyjae Spears was upgraded to limited participation, and Tony Pollard practiced fully.

More fantasy football injuries to monitor

Ladd McConkey did not practice Thursday after being limited Wednesday, creating another major concern for fantasy managers. Mike Evans also did not practice despite doing some light work, while Chris Godwin practiced fully.

The Seahawks provided some encouraging news with Zach Charbonnet’s practice window opening, while Jadarian Price went from limited participation to no practice. That Seattle backfield could look very different once Charbonnet is ready to return.

Jayden Daniels remained limited Thursday as he works his way back from his elbow injury, and he will miss this weekend’s game, while Caleb Williams missed another practice for Chicago. DJ Moore also remained limited.

Jalen Coker was able to practice on a limited basis, while Jordyn Tyson’s return to practice is not anticipated next week. Keenan Allen was added to the injury report as a limited participant, Jaylen Wright practiced fully, and Rachaad White missed another practice.

Kenyon Sadiq was again limited, leaving fantasy managers with plenty of injury situations to monitor before final lineups are locked. With so many major players carrying injury designations, Friday’s practice reports and official game statuses will be especially important.

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